Emory Vaccine Center and the Centers for Disease Control and Prevention states that immunity given against the mumps virus appears insufficient in a few youngsters who were vaccinated in childhood. This shows that there is a need for better understanding related to vaccine given for mumps.
Across the united State there had been several mumps outbreaks among college students in the last 15 years. The two possibilities could be waning vaccine induced immunity and a difference between the strain of mumps virus and the vaccine strain. “Overall, the MMR vaccine has been great, with a 99 percent reduction in measles, mumps and rubella disease and a significant reduction in associated complications since its introduction,” says Sri Edupuganti, MD, MPH, associate professor of medicine (infectious diseases) at Emory University School of Medicine and medical director of the Hope Clinic of Emory Vaccine Center. “What we’re seeing now with these mumps outbreaks is a combination of two things—a few people were not making a strong immune response to begin with, and the circulating strain has drifted away from the strain that is in the vaccine.”
CDC scientist and Emory did a study on 71 youngsters aged 18 to 23 in the Atlanta region. Although 69 of them had received both MMR doses, 80% of them received 10 years before enrolling in the study. 93% of them had antibodies in them, but 10% of them had no detachable mumps specific memory B cells, which produces the antiviral antibodies as part of the exposure to mumps virus and also the antibodies from the participants did not neutralize wild type mumps cells efficiently. The paper concludes that at least six participants may be potentially suspected with currently circulating wild type mumps strain.
Mumps vaccine strain known as “The Jerry Lynn mumps vaccine strain” in the MMR vaccine was originally cultured from scientist daughter’s throat in the 1960s. The problem has become messy, because the current circulating strain is genetically from the vaccine strain.